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Quote: Welcome to Journal Watch Breast Cancer Alerts ***********************************************************ADVERTISEMENTStart Your 14-Day FREE Trial to Journal Watch OnlineKeeping up with the latest developments in medicine is central to your careof patients. But with all you do as a clinician, how do you find time to stay informed? You do what 350,000 physicians do: Stay informed with Journal Watch Online. Start your 14-Day FREE TRIAL today! https://secure.jwatch.org/ecom/subscribe/sub_promopage.aspx?promo=OOJJJZ14&cpc=OJOREGFE0309 ***********************************************************Journal Watch is editorially independent and does not endorse any company, product, or service. BREAST CANCER for February 3, 2010 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Soy: Safe and Perhaps Even Beneficial for Breast Cancer Survivors[Women's Health | Summary and Comment | Subscription Required] In a Chinese study, dietary soy intake was inversely related to breast cancer recurrence and mortality.By Andrew M. Kaunitz, MDJanuary 14, 2010Covering: Shu XO et al. JAMA 2009 Dec 9; 302:2437 http://womens-health.jwatch.org/cgi/content/full/2010/1.../4?q=topic_breastcan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Modeling Sound Prognostic Decisions Among BRCA Mutation Carriers[Women's Health | Summary and Comment | Subscription Required] Computer simulation can estimate survival advantages associated with prophylactic surgeries and nonsurgical strategies.By Andrew M. Kaunitz, MDJanuary 7, 2010Covering: Kurian AW et al. J Clin Oncol 2009 Dec 7; Stadler ZK and Kauff ND. J Clin Oncol 2009 Dec 7; http://womens-health.jwatch.org/cgi/content/full/2010/1.../7?q=topic_breastcan _______________________________________________________________________ FREE FULL-TEXT ARTICLE Summary and Comment Soy: Safe and Perhaps Even Beneficial for Breast Cancer SurvivorsIn a Chinese study, dietary soy intake was inversely related to breast cancer recurrence and mortality. Because soy isoflavones have estrogenic properties, the safety of soy consumption by breast cancer survivors has been questioned. In a cohort study conducted in Shanghai, women (age range, 20-75) who received diagnoses of breast cancer from 2002 to 2006 were followed for a median of 3.9 years. Soy intake was assessed with a validated survey that was designed to measure consumption of soy-containing foods in Chinese people. Among 5033 evaluable participants, 534 recurrences or breast cancer-relateddeaths occurred. Dietary soy intake was inversely related to breast cancer recurrence and mortality. Compared with the lowest quartile of soy intake, the highest quartile was associated with an adjusted hazard ratio of 0.7. This inverse relation was observed in women regardless of tumor estrogen-receptor status or tamoxifen use. Comment: Although soy consumption in China is substantially greater than inthe U.S., dietary soy intake (think tofu and soy milk) is growing rapidly in the U.S. Although its short follow-up limits this study's clinical implications, the findings provide reassurance about the safety of soy consumption by women who have breast cancer. Soy isoflavones and tamoxifen both bind to estrogen receptors. The finding that high dietary soy consumption can improve breast cancer outcomes to a degree similar to tamoxifen suggests that a trial designed to compare the efficacy of tamoxifen and soy as adjuvant therapies in women who have completed initialtherapy for breast cancer should be considered. -- Andrew M. Kaunitz, MD Published in Journal Watch Women's Health January 14, 2010 Citation(s): Shu XO et al. Soy food intake and breast cancer survival. JAMA 2009 Dec 9; 302:2437. 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