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Quote: Interactions With Drugs and Medicines Grapefruit has serious interactions with many commonly prescribed medications. Grapefruit juice inhibits a special enzyme in the intestines that is responsible for the natural breakdown and absorption of many medications. When the action of this enzyme is blocked, the blood levels of these medications increase, which can lead to toxic side effects from the medications. Grapefruit juice research has suggested that flavonoids and/or furanocoumarin compounds are the substances that act to block the enzyme in the intestines that normally ####bolizes many drugs. The grapefruit juice-drug interaction can lead to unpredictable and hazardous levels of certain important drugs. These medications should not be consumed with grapefruit juice unless advised by a doctor: